BioProcess Development - BioProcessing

C2B Platforms

Chem-to-Biotech

works by substituting or modifying traditional chemical transformations by biotechnological fermentation based approaches.

includes either the use of isolated enzymes or microorganisms (wild type or recombinant bacteria and yeasts) in single or multiple transformation steps.

The C2B® process works in 2 stages:

C2B® Pathway

The

Pathway is based on current information available in bibliographic reports and databases of enzymes, metabolic pathways and microorganisms. It focuses on establishing proof of concept of the biotechnological transformation (reaction/s to be substituted) on a lab scale. If enzyme/s are not commercially available, they can be obtained by fermentation of bacteria and yeast, or even by cloning gene/s onto host bacteria using recombinant DNA-technology and recovering it. Finally, experimental assays to test enzyme activity in model-type substrates and in the target substrates, including yield characterization in different reaction conditions are performed.

C2B® Factory

The

Factory is based on the principle of the

Pathway. The

Factory is applied in order to attain the experimental conditions which lead to the most efficient biotechnological transformation and focuses on achieving a consistent bioprocess. These activities are addressed to scaling up the process and to test the feasibility for implementation on an industrial scale. Some processes can be improved only by media optimization. Others require advanced bioreactor-engineering approaches such as continuous culture on perfusion modules or reactors with immobilized enzymes or microorganisms. Some other approaches include metabolic engineering through increasing genetic dosage of a specific enzyme, or silencing of other ones that allow altering the behavior of the microorganisms by forcing physiological growth conditions.

C2B® project management

is a step by step methodology which works on any project by stages. Usually a

project comprises one or more than one of the following stages:

PHASE I

PHASE II

PHASE III

PHASE IV

PHASE V

This methodology offers our clients the option of not going onto the next phase based on objective data and their own interests. If the results obtained in a phase make it clear that this decision is the most appropriate the project is interrupted, or redirected.

solutions are always cost oriented.

C2B® proprietary products

also conducts its own public funded (EU) research and cooperates with several public and private international institutions. The aim of this strategic work is to increase, in a synergistic way, the exploring capabilities of

in developing innovative biosolutions for improving the potentiality of implementing it successfully.

Some of the areas where our scientists are actually working are:

	Biotransformations with low water soluble compounds

	Biotransformations of aromatic compounds

	Arylpropionic and Arylacetic anti-inflammatory biosynthesis

Legal information · Site map · info@arquebio.com · Tel. (0034) 93 586 89 60 · Web design Barcelona: Montaweb.com